Chise is the main female character of Saikano. She's is a shy, clumsy girl with very little self-esteem and has poor grades in everything except for World History. She was constantly hospitalized in Tokyo during her elementary years, and thus, has very few friends (except for Akemi). She starts dating Shuji, with Akemis help, and tries to make her relationship work with him despite his apparently aloof personality. However, Chise is very inexperienced and does not know much about relationships, to the point she reads shoujo manga for advice. She was turned into the ultimate weapon against her will, and the series revolves around her and her fading humanity. Chise tries to come to terms with her new weapon body by convincing herself that shes protecting the one she loves, but comes to admit to herself that the only thing she can do is to destroy.