Isamu is a young Trainer from Pallet Town who received a Pokedex from Professor Oak and was sent on a quest to find out more about Pokemon.
Isamu encounters a violent male Clefairy on his way to Professor Oak's lab, and together they defeat a giant Nidoran by accident. When Clefairy follows Isamu to the laboratory, Isamu chooses to travel with the Clefairy because he finds his antics amusing.
Unlike his rival, Isamu doesn't catch a lot of Pokemon. He has two (later three) favorites, which he keeps outside their Poke Balls. He has caught several others, including Articuno, but never uses them in battle.
He continues his journey in Pokemon Ruby-Sapphire, the sequel to Pokemon Pocket Monsters that takes place in Hoenn, and in Pocket Monsters DP, the second sequel of Pokemon Pocket Monsters that takes place in Sinnoh.
His rival is Kai Midorikawa.
(Source: bulbapedia.bulbagarden.net)