Lisa played a minor supporting role in the third movie. She met up with Ash and his friends and challenged him to a battle. In the subsequent confrontation, Lisa's Girafarig and Butterfree defeated Ash's Chikorita and Bulbasaur, but his Totodile, Noctowl and Cyndaquil defeated her Granbull, Aipom and Mankey, and Ash's Pikachu and her Quagsire came to a draw, and Ash won the battle.
Later on in the movie, when Entei was crystallizing the town, Lisa gave Ash her Pokegear so he could keep in contact with Professor Oak while he and his friends went into the crystal tower to investigate and rescue Ash's mother. Lisa hasn't been seen since the third movie.